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Biosketch
CURRICULUM VITAE
Date revised: 6/26/2007
Name: Jay Alan Fishman
Office Address: Infectious Disease Division, Massachusetts General Hospital, GRJ 504;
55 Fruit Street, Boston, MA, 02114
Home Address: 383 Linden Street, Wellesley Hills, MA, 02481
Date of Birth: February 2, 1954
Place of Birth: New York, New York
Education:
1975 BA/BS University of Pennsylvania (Immunology and Biology)
1979 MD Johns Hopkins University School of Medicine
Postdoctoral Training:
Clinical Training:
1979-1980 Intern in Internal Medicine, Massachusetts General Hospital, Boston
1980-1981 Resident, Internal Medicine, Massachusetts General Hospital, Boston
1981-1982 Clinical Fellow in Infectious Diseases, Massachusetts General Hospital, Boston
Research Fellowships:
1981-1985 Clinical and Research Fellow in Medicine (Infectious Disease) Massachusetts General Hospital
1981-1982 Research Fellow in Medicine, Harvard Medical School
1982-1985 Research Fellow, Molecular Biology, Massachusetts General Hospital
1982-1985 Research Fellow in Genetics, Harvard Medical School
1987-1989 MacArthur Foundation Fellow in Molecular Parasitology, Yale University School of Medicine
Licensure and Certification:
1981 Medical License, Commonwealth of Massachusetts
1993 American Board of Internal Medicine Certified, Internal Medicine
1996 American Board of Internal Medicine Certified, Infectious Diseases
Academic Appointments:
1985-1992 Instructor in Medicine, Harvard Medical School
1987-1989 Associate Research Scientist, Department of Medicine, MacArthur Foundation Fellowship, MacArthur Center for Molecular Parasitology, Yale University School of Medicine, New Haven, CT.
1992-1998 Assistant Professor of Medicine, Harvard Medical School
1997- Visiting Scientist, Massachusetts Institute of Technology, Cambridge, MA.
1999- Associate Professor of Medicine, Harvard Medical School
Hospital or Affiliated Institutions Appointments:
1985-1987 Clinical Assistant in Medicine, Massachusetts General Hospital, (Infectious Disease Unit)
1987-1990 Assistant in Medicine, Massachusetts General Hospital
1990-1992 Consultant, Harvard University Health Services, Infectious Diseases, Cambridge, MA.
1991-1993 Assistant Physician, Massachusetts General Hospital
1992- Staff Physician, Transplant Unit (Surgery), Massachusetts General Hospital
1992-1995 Consultant in Parasitology, Massachusetts General Hospital
1993-1998 Associate Physician, Massachusetts General Hospital
1994- Consultant, Infectious Disease, North Shore Medical Center, Salem Hospital
1995-2001 Clinical Director, Transplantation Infectious Disease Program, MGH
1999- Physician, Massachusetts General Hospital
2001- Director, Transplantation Infectious Disease and Compromised Host Program, MGH.
2006- Associate Director, MGH Transplant Center
Other Professional Positions and Major Visiting Appointments:
1994- Senior Scientific Staff, Shriners’ Hospital For Children, Boston Burns Unit, Boston, MA
1997- Visiting Scientist, Massachusetts Institute of Technology
1997- Scientific Advisory Committee, MIT Clinical Research Center, Cambridge.
1997- Consulting Medical Staff, Shriner’s Hospitals for Children, Boston Unit
2003- Research Affiliate, Harvard-MIT Division of Health Sciences and Technology
Hospital and Health Care Organization Clinical Responsibilities:
1985- Massachusetts General Hospital, Consultation in Infectious Disease (Attending physician 4 months/year)
1995-2001 Clinical Director, Transplantation Infectious Disease, MGH
2001- Director, Transplantation Infectious Disease and Compromised Host Program, MGH
Major Administrative Responsibilities:
2001- Director, Transplantation Infectious Disease and Compromised Host Program
1993-2003 Director, Infectious Disease Research Laboratories, Charlestown Campus, M.G.H.
1990-2002 Director, Postgraduate Education, Infectious Diseases Division, M.G.H.
Major Committee Assignments:
Harvard Medical School:
1982-1985 Curriculum Committee
1983-1987 Admissions Committee
1983-1986 New Pathway Planning Group
1983-1987 Subcommittee on Human Biology (Defense Mechanisms)
1990- Course Director, Harvard CME Postgraduate Course: Infectious Diseases of Adults
1990-1992 Infection Control Committee, Harvard University Health Service, Cambridge, MA.
1991-2001 Senior Fellow, Oliver Wendell Holmes Society
1991-1993 Graduation Honors Research Committee
1991-2001 Advanced Biomedical Science Program Committee
1994-1996 Admissions Committee
2001- Xenotransplantation Advisory Committee, Chair (Committee on Microbiologic Safety)
Massachusetts General Hospital:
1985-1987 Subcommittee on Research Teaching, Committee on Research
1990-1995 Committee on Teaching and Conferences, Infectious Disease Unit
1992-1995 Committee on Research
1993-2001 Curriculum Committee, Infectious Disease Unit
1995-2001 Director, Postgraduate Education, Infectious Disease Unit
1995-2000 Telemedicine Committee, Subcommittee on Postgraduate Education
1996-2000 Xenotransplantation Advisory Committee
1998- Advisory Committee, Bone Tissue Bank
2002 Chair, Fever and Neutropenia Guidelines Committee
2003 Chair, Antifungal therapy Guidelines Committee, (Partners Healthcare)
2003- Transplant Steering Committee
2003- LVAD Taskforce MGH
2006 Fungal Therapies Guidelines Committee
2006 Executive Committee, Immunology Training Grant (D. Sachs, PI)
Regional:
1995-2000 Research Committee, Shriners’ Burns Institute, Boston, MA.
1995- Infectious Disease Advisory Committee, New England Organ Bank
1997-2000 Harvard University School of Public Health, Committee on Xenotransplantation
1997-2000 Interspecialties Committee, Massachusetts Medical Society (representative of American College of Physicians)
1997-2000 Massachusetts Medical Society, House of Delegates
1997- Scientific Advisory Committee of the MIT Clinical Research Center, Cambridge, MA.
National/International:
1990 Study Section NIH-NIAID: National Cooperative Drug Discovery Group for the Treatment of Opportunistic Infections Associated with AIDS (SRC-AIDS-90-17)
1991 Study Section: RFA-NIH-NIAD 91-AI-07 Adult AIDS Clinical Trial Units (C5,C6)
1992 Chairperson; Special Review Committee (NIH-NIAID-92-08) Model Development and Therapies for Cryptosporidium
1993 Chairperson; Special Review Committee (NIH-NIAID-93-25). Drug Development for Toxoplasmosis in AIDS
1995-2000 American College of Physicians Health and Public Policy Committee
1995-2000 Food and Drug Administration Advisory Committee on Xenograft Transplantation.
1995- Food and Drug Administration, Consultant, Center for Biological Evaluation and Research, Biologic Response Modifiers Advisory Committee (renewed 2004)
1995- Infectious Disease Advisory Committee, New England Regional Organ Bank, UNOS
1996-2001 National Institutes of Health, Committee on National Xenograft Transplantation Registry
1998-2004 Executive Committee, Section on Infectious Disease, Transplantation Society
2001- Data Safety Monitoring Board, NIH/NIAID – Transplantation and Immune Tolerance Network
2003 Ad Hoc Study Section: Pathogenesis Of Polyomavirus Associated Nephropathy, RFA-03-019, NIAID
2005-2006 Program Committee (Infectious Disease Chair), World Transplant Congress
2005- Member, Operations Committee, Organ Procurement and Transplantation Network/ United Network for Organ Sharing
2005- Chair, Disease Transmission Advisory Group (DTAG), Sentinel Network for Infections in Transplantation, UNOS
2006- Special Advisor to the Council of the International Xenotransplantation Association for Infectious Diseases
American Society of Transplantation
1997-1998 Co-Chair: Committee on Infectious Diseases
1998-2000 Chair: Committee on Infectious Diseases
1998-1999 Co-Chair: Xenotransplantation Committee
1999-2000 Chair: Xenotransplantation Committee
2000-2003 Councilor, Board of Directors
2000-2003 Education Committee
2000-2002 Chair, Ad Hoc Committee on Conflicts of Interest
2001-2002 Development Committee
2001- Joint Executive Committee, AST/American Society of Transplant Surgeons
2002-2003 Co-Chair, Development Committee
2003-2004 Chair, Development Committee
2003-2004 President-Elect, American Society of Transplantation
2004-2005 President, American Society of Transplantation
2005-2006 Past-President, American Society of Transplantation
Professional Society Involvement
1979- American Association for the Advancement of Science
1981-1999 Massachusetts Medical Society (Representative, House of Delegates, 1997-1999)
1981- American Society for Microbiology
1983- American Society for Tropical Medicine and Hygiene
1986- American Federation for Clinical Research
1987- Society of Protozoologists
1989- Infectious Diseases Society of America, Fellow (1996)
1991- American College of Physicians, Fellow (1994)
1991- American Thoracic Society
1993- American Society of Transplantation (President, 2004-2005)
1993- Immunocompromised Host Society
1999- Transplantation Society (Executive Committee, Infectious Disease Section)
2003-2005 Xenotransplantation Society (Executive Committee)
Editorial Boards
1997- Transplantation (member)
1998-2003 Graft (member)
1998-2005 Transplant Infectious Disease (Associate Editor, Basic Science)
2001- Xenotransplantation (Associate Editor)
2002- American Journal of Transplantation (Associate Editor)
Ad hoc reviewer: New England Journal of Medicine, Journal of Immunology, Journal of AIDS and Retrovirology, Antimicrobial Agents and Chemotherapy, Journal of Infectious Diseases, Infection and Immunity, J. Virology, J American Society of Nephrology.
Awards and Honors
1971 National Merit Scholar
1971-1975 University of Pennsylvania, General Honors Program
1975 University of Pennsylvania, Graduate Magna Cum Laude, Double Major (Biology and Immunology)
1978 Johns Hopkins University School of Medicine, Research Honor Prize
1979 Johns Hopkins University School of Medicine, Research Honor Prize
1979 NIH, Special Student, Clinical Immunology
1983 National Academy of Science, Travel Grant Award
1987-1992 Clinical Investigator, National Heart, Lung, and Blood Institute, N.I.H.
1986-1987 American Foundation for AIDS Research Research Award
1987-1989 Fellowship, MacArthur Foundation for Molecular Parasitology, Yale University School of Medicine
1989 Member, Infectious Disease Society of America
1989-1994 Principal Investigator, Core Facility for the Growth and Isolation of Pneumocystis carinii (PO1HL43510)
1991-2007 Listed, Marquis Who's Who in Science and Engineering (1st-8th Editions)
1991-1992 American Lung Association Research Award
1994 Fellow, American College of Physicians
1996 Fellow, Infectious Disease Society of America
1999 Poster of Distinction, American Society of Transplantation, Chicago, IL.
2001 Visiting Professorships
Toronto General Hospital, Toronto, Canada
Groningen University Hospital, The Netherlands
2002 Clinical Career Achievement Award, American Society of Transplantation
2003 President-Elect, American Society of Transplantation
2003-2005 Councilor, International Xenotransplantation Society
2003 Visiting Professorships
Yale University School of Medicine, New Haven CT.
University of Tennessee School of Medicine, Memphis, TN.
Drexel University School of Medicine, Philadelphia, PA.
2003-2005 Honorary Member, International Society for Heart & Lung Transplantation
2004-2005 President, American Society of Transplantation
2004 9th Aaron Mannett Transplant Lecturer, Lankenau Hospital, Philadelphia, PA.
2004-2006 Best Physicians in America, Infectious Diseases
2005- Best Doctors in America (Top 4% of US Physicians)
2005 Visiting Professor, Swiss National Medical School of Lausanne, Switzerland
2005 Representative of U.S. Transplant Physicians and Surgeons at First World Transplant Day, World Health Organization, Geneva, Switzerland
2006 Best of Boston, Infectious Disease Physicians
2006 Visiting Professor, Harry F. Dowling Professor, University of Illinois, Chicago.
Consultant
Past Appointments:
Glaxo-Wellcome Inc: Opportunistic Infections Advisory Committee; Transplantation Advisory Committee
BioTransplant/ImergeBT, Inc, Cambridge, MA: Studies of xenotransplantation
Roche Laboratories: Visiting Faculty-- CMV Infection in Transplantation
Diacrin Incorporated, Retroviruses in Clinical Xenotransplantation
Genzyme, Inc. Infectious Disease Products
Novartis, Safety Advisory Board, Xenotransplantation
Novartis Data Safety Monitoring Board, FTY720
Novartis, Chair, Infectious Disease Advisory Committee
Fujisawa Healthcare, Transplantation Advisory Committee
Athelas, Geneva, Scientific Advisory Board
Current: Gilead, Antifungal Advisory Committee
Pfizer, Antifungal Advisory Panel
Merck, Infectious Disease, Vaccines
Astellas, Immunology and Infectious Diseases
Primera, Scientific Advisory Board
Food and Drug Administration, Center for Biologics Advisor (Xenotransplantation)
Research Support:
(Past)
1986-1989 MacArthur Foundation Molecular Parasitology Research Program (Co-PI, Project Director): Molecular Biology of Pneumocystis
1987-1992 National Heart, Lung, and Blood Institute (Clinical Investigator, KO8, P.I): The Pathogenesis of infection due to P. carinii.
1986-1988 American Foundation for AIDS Research (P.I.): Novel vaccine strategies for P. carinii
1989-1994 N.I.H./PO1: Co-PI and Project Director: Core Facility for the Growth and Isolation of Pneumocystis carinii (PI) and Pathogenesis of Infection due to P. carinii (Co-PI)
1991-1993 American Lung Association Research Award: (P.I.): Molecular cloning of topoisomerase from P. carinii
1995-1999 R.W. Johnson Foundation (PI) Atovaquone/Ofloxacin Prophylaxis in Transplantation.
1996-1998 NIH: SRO1CA61507 (consultant): IL2 in mismatched Bone Marrow Transplants
1996-1999 NIH: RO1-HL51957 (PI): Alveolar Macrophage Responses to Mycobacterial Cell Wall
1995-1999 Shriner’s Burns Institute (PI) Susceptibility to pneumonia following thermal injury
1995-2000 BioTransplant Inc. (PI) Retroviral activation in xenograft recipients
1997-2001 NIH: PO1A13975502 (subproject, collaborator, M. Sykes, PI) Immune Restoration by Fetal Pig Thymus Grafts in Murine Models
1999-2001 Microbia, Inc. Murine susceptibility to bioengineered yeast. (Fishman , PI)
2001-2005 (Sachs) P01 Tolerance approach to xenotransplantation Fishman PI: Project 4: Infectious risks of xenotransplantation
Active
1998- NIH: Transplantation Immunology Training Grant, Investigator (D. H. Sachs, PI)
2000-2006 Fujisawa Incorporated: Educational Programs in Infectious Diseases in Compromised Hosts
2005-2009 (Sachs PI) P01 Tolerance approach to xenotransplantation JA Fishman - Project PI: Infectious risks of xenotransplantation (NIHPO1-AI45897-01)
2003-2005 Roche Inc, Educational Programs in Clinical Transplantation
2004-2009 NIH-CTOT Center Grant: Novel Therapies of Chronic Allograft Dysfunction (M. Sayegh PI) NIH U01AI063623-01 (Co-investigator)
2005-2006 ROTRF: Molecular Studies of Lymphoma in allogeneic transplantation: a large animal model Molecular analysis of oligonucleotide gene arrays in lymphoma.
(Planned/Pending)
R01: Viral studies in xenotransplanation
NIH:RO1 (C. Huang PI, co-investigator) Hematopoietic Cell Transplants for Non-Malignant Disease-pending
Clinical Trials:
1995-1996 Ganciclovir in solid organ transplant recipients (Phase III) – completed
1996-1997 Pharmacokinetics of Atovaquone in solid organ transplant recipients (Phase I-II) -- completed
1997-1998 Atovaquone prophylaxis in solid organ transplant recipients intolerant of TMP-SMZ (Phase II-III) –completed 12/98
1997-1998 Randomized trial of Atovaquone vs. TMP-SMZ in recipients of allogeneic bone marrow transplants (Phase II-III) – completed (Co-PI, Dr. T. Spitzer)
1999- A mixed chimerism approach to renal transplantation (T. Spitzer, PI) on-going
2000-2001 Linezolid for resistant gram-positive infections in transplant recipients
2000-2001 Voriconazole for resistant fungal infection: a compassionate use trial (Pfizer Inc)
2003-2006 Prospective monitoring of invasive fungal infections (Planning Committee) (Astellas)
2004-2009 NIH-CTOT Center Grant: Novel Therapies of Chronic Allograft Dysfunction (M. Sayegh PI) NIH U01AI063623-01 (Co-investigator)
2004- Axiom/Astellas Healthcare: PATH Registry of Invasive Fungal Infections
2005-2007 Posaconazole compassionate use trial - (site PI)
2005- NIH: BAA (C. Larsen, PI) Immune Function and Biodefense in Children, Elderly, and Immunocompromised Population (Consultant)
Teaching:
Medical/Graduate School:
1974-1975 Lecturer, University of Pennsylvania, Graduate Dept. of Biology, in Developmental Biology/Immunology
1979-1981 House Officer, Massachusetts General Hospital, Harvard Medical School Students
1981-1982 Clinical Instructor of Medical Students at Harvard Medical School and of Housestaff at Massachusetts General Hospital
1983-1991 Instructor, Pathophysiology of Infectious Disease (laboratory and conference leader, Harvard Medical School (708.0)
1985-1987 Medical Attending, Baker Medical Service, M.G.H. (1 month per year)
1985-2004 Infectious Disease Unit, Ward Service Attending (2 months per year) (HMS 703.0)
1985-1987 Oliver Wendell Holmes Society, Identity and Defense, (HMS 703.0), Lecturer, Course and Laboratory Originator and Instructor
1990- Infectious Disease Attending, Transplantation Service, M.G.H. (3 months per year)
1994- 2001 Oncology and Infectious Disease; Resident Teaching, M.G.H. (7 lectures/year)
1995-2000 Oliver Wendell Holmes Society-based Independent Study Preceptor (HO900/950)
1997-2004 Infectious Diseases Course for Intensive Care and Anesthesia (14 lectures per year)
A. Invited Presentations
1988,90,93,95 Medical Grand Rounds, M.G.H.: Pneumocystis carinii
1989-1993 Infectious Disease/AIDS Conference:
New England Medical Center, Boston
University of Maryland Hospital, Baltimore, MD.
Grady Hospital, Atlanta, GA.
Downstate-King's County Hospital, Brooklyn, NY
1992-1995 Medical Grand Rounds: “Pneumocystis carinii: Bench and Bedside”
Yale-New Haven Hospital, New Haven, CT
Mount Sinai Hospital, N.Y.
Children's Hospital, Boston, MA.
St. Luke's-Roosevelt Hospital, N.Y.
Dartmouth-Hitchcock Medical Center, Lebanon, NH
1995-1996 Opportunistic Infections in Transplantation
Medical/Surgical Grand Rounds, M.G.H.
Latin American Transplantation Society, Curitiba, Brazil
ASTP, Transplantation Fellows Conference, New Orleans, LA
University of Cincinnati School of Medicine
University of Minnesota School of Medicine
Visiting Professor, University of Tubingen, Germany
ASTP Transplantation Fellows Research Conference, New Orleans
Xenosis and Xenotransplantation
American Society of Transplant Surgeons.
Institute of Medicine/National Academy of Sciences.
National Congress on Animal Safety, Atlanta, GA
Pediatric Nephrology Congress, Washington, D.C.
American Society of Nephrology, New Orleans
Parasitology Lectures - M.G.H.
Protozoan Infections
Flukes and Cestodes
Parasites in the Compromised Host
Pneumocystis carinii: Oncology Conference, M.G.H.
I.D. Conference, Brigham & Women’s Hospital
Pneumonia - Nosocomial and Community Acquired: Internal Medicine Course, M.G.H.
Opportunistic Infections: Internal Medicine Course, Infectious Disease Course, M.G.H.
1997 Xenotransplantation and Infectious Diseases
International Bone Marrow Transplantation Registry Meeting (Scottsdale, AZ)
Harvard University School of Public Health, Boston, MA
National Kidney Foundation, Dallas, TX
American Society of Transplant Physicians, Chicago, IL (Program Chair)
Harold J. Neu Symposium, Chicago IL.
Modern Plagues: Emerging and Re-emerging Infectious Diseases, Massachusetts Institute of Technology, Cambridge, MA.
Memorial Sloan Kettering Institute, Infectious Disease Rounds, New York, NY
Cardiology Grand Rounds, M.G.H., Boston
Molecular Cloning and Expression of Porcine Retrovirus
Transplantation Biology Research Center, MGH, Boston, MA
Cross-species Infectivity and Pathogenesis Conference, NIH, Bethesda MD
Strategies for the detection of porcine retrovirus, Session Chair, US-Food and Drug Administration, Bethesda, MD
Molecular cloning of porcine endogenous retrovirus (Session Chairperson “regulation of Xenotransplantation”), 4th International Congress on Xenotransplantation, Nantes
Health Canada: Workshop on Xenotransplantation, Toronto, CA.
Opportunistic Infections
Pulmonary Critical Care Lecture Series, M.G.H.
Pulmonary Infections in AIDS, Infectious Diseases Of Adults, M.G.H., Boston, MA
Infections in Transplantation (Invited speaker, Workshop, ICAAC, Toronto, Canada)
Pneumonia - Nosocomial and Community Acquired
Infectious Diseases Of Adults, M.G.H., Boston, MA
Internal Medicine Course, M.G.H.
Surgical Infectious Diseases Course, M.G.H., Boston, MA.
Infection in Burns and Trauma
American Burn Association, New York, NY
Surgical Infectious Diseases Course, M.G.H., Boston, MA.
1998 Infections in Xenotransplantation
Infection and Immunity Conference, Mayo Clinic, Rochester, MN
Cardiology Grand Rounds, MGH, Boston, MA.
Infectious Disease Inter-city Conference, Brigham and Women’s’ Hospital, Boston, MA.
Infection in Xenotransplantation, New York Academy of Sciences, New York, NY
Clinical Approach to Prevention of Xenosis, Foundation for Health Sciences, Madrid, Spain
Surgical Grand Rounds, Stanford University
Infection in Allotransplant Recipients
Medical Grand Rounds, Mayo Clinic, Rochester, MN
Leukosite, Inc., Cambridge, MA
U.S. Public Health Service, Developing U.S. Public Health Policy in Xenotransplantation, Bethesda, MD (“Xenosis: The Lessons of Allotransplantation for Xenotransplantation”)
Clinical Nephrology-Bench to Bedside, Harvard Medical School Postgraduate Course
Infectious Disease Grand Rounds, Stanford University
Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Meet-the- Professor, Denver, CO.
Pneumonia - Nosocomial and Community Acquired
Infectious Diseases of Adults, MGH, Boston, MA
Anesthesia Conference, MGH, Boston, MA.
1999 Infections in Allotransplantation
American Society of Transplantation 1999 Winter Symposium, Kapalua, Maui, HW
American Society of Transplantation, Fellows Symposium, Toronto, Canada
American Society of Nephrology, Miami Beach, FLA
Medical Grand Rounds, Duke University School of Medicine (Visiting Professor)
Plenary Lecture, American Society of Nephrology, Miami, FLA
Infections in Xenotransplantation
Surgical Grand Rounds, Albany Medical Center, Albany, NY
Plenary Lecture, ICAAC, San Francisco, CA
Fungal Infection in Transplantation
Focus on Fungal Infections, San Diego, CA
Surgical Grand Rounds, Stanford University School of Medicine, CA
Surgical Grand Rounds, UCLA School of Medicine, Los Angeles, CA
Plenary Lecture, International Liver Transplantation Society, Pittsburgh, PA.
Israel Penn Symposium, Scottsdale, AZ
2000
Infections in Allotransplantation
Plenary Lecture, American Society of Nephrology, Miami, FLA
American Kidney Foundation, Atlanta, GA
International Immunocompromised Host Society, Halifax, Canada
National Kidney Foundation, Bethel , ME
Toronto General Hospital, Toronto, Canada
American Society of Nephrology, Toronto, Canada
Johns Hopkins University, Baltimore, MD.
Infectious Disease Society of America, Meet-the-Professor, New Orleans, LA
Infections in Xenotransplantation
Surgical Grand Rounds, Albany Medical Center, Albany, NY
Plenary Lecture, ICAAC, San Francisco, CA
Plenary Lecture: XVIII International Congress of the Transplantation Society, Rome
Keynote Lecture, OECD Conference on Xenotransplantation, Paris, France
Fungal Infection in Transplantation
3rd Congress of the Latin American Transplant Society, Punte del Este, Uruguay
American Society of Transplantation, Chicago, IL
XVIII International Congress of the Transplantation Society, Rome
Toronto General Hospital, Toronto, Canada
Hahnemann University Hospital, Philadelphia, PA.
Jeannes Hospital, Philadelphia, PA.
University of Miami Jackson Memorial Hospital, Miami, FLA
Antimicrobial Resistance in Transplantation
Plenary Lecture, International Congress of Transplantation Infectious Disease, Stockholm, Sweden
University of Miami, Miami, FLA
University of Chicago, Chicago, IL
The Human Condition and Xenotransplantation
Fundacio Luso-Americana para o Desenvolvimento, Lisbon, Portugal
AIDS and Transplantation:
Consensus Conference on Transplantation in AIDS, Bethesda, MD
Transplantation Society Plenary Lecture, Rome, Italy
International AIDS Malignancy Conference 2000, Bethesda, MD
Plenary Lecture: XVIII International Congress of the Transplantation Society, Rome
Visiting Professorships
Toronto General Hospital, Toronto, Canada
Groningen University Hospital, The Netherlands
2001
Infections in Clinical Allotransplantation
Transplantation Society of Brazil, Victoria, Plenary Lecture
American Society of Transplantation Winter Symposium, Plenary Lecture, Hawaii
University of Texas-San Antonio, Surgical Grand Rounds, San Antonio, TX
Baylor University, Houston, TX
Ottawa General Hospital, Medical Grand Rounds, Ottawa, CA.
Yale University, Infectious Disease Grand Rounds, New Haven, CT.
AST Fellows Symposium, San Jose, CA.
American Society of Nephrology Postgraduate Course, San Francisco, CA.
Viral Infections in Transplantation
Research Seminar, Immune Tolerance Network, Washington, D.C.
AST Fellows Symposium, San Jose, CA.
Fungal Infection in Transplantation
Transplantation Society of Brazil, Victoria, Plenary Lecture
Transplant 2001, Plenary Lecture, Chicago, IL
Antimicrobial Resistance in Transplantation
Transplant 2001, Symposium Chair, Chicago, IL.
Henry Ford Hospital, Medical Grand Rounds, Detroit, Michigan
Xenotransplantation and Infection:
IDology Society of Ottawa, Ottawa, CA
Plenary Session, ICAAC, Chicago, IL
Plenary Session, American Society of Histocompatibility and Immunology
(ASHI), San Francisco, CA
New Infectious Agents in Transplantation
Infectious Disease Society of America (IDSA) Plenary Session, San Francisco
CMV and Emerging Viruses in Transplantation, Transplant 2001, Chicago, IL
Infections in the Immunocompromised Host
Taiwan Infectious Disease Society, Taipei, Taiwan.
Update on Pneumonia
Taiwan Infectious Disease Society, Taipei, Taiwan.
BK Virus in Transplantation
Transplant 2001, AST/ASTS, Chicago, IL.
2002
AST Winter Symposium: Transplantation meets Infection: Symposium co-chair
New Pathogens in Transplantation
Massachusetts General Hospital, Cardiac Transplant Rounds
Lahey Clinic, Burlington, MA, Transplant Surgery Conference
Emory University, Atlanta, GA.
Washington Hospital Center, Transplantation Section, Washington, D.C.
Plenary Speaker, XXI Congress of the Scandinavian Transplantation Society, Reykjavik, Iceland
University of Nebraska, Omaha, Nebraska, Surgical Grand Rounds
University of Washington School of Medicine, Seattle, WA.
Fungal Infections in Transplantation
University of Osaka, Japan
University of Kentucky, Lexington, KY.
Oregon State University Health Sciences Center, Portland, OR.
Housestaff Conference, MGH, Boston, MA.
Viral Infections in Transplantation
Plenary Session, American Transplant Congress, Washington, D.C.
AST Fellows Conference, Dallas, TX.
American Society of Nephrology, Post-graduate Course, Philadelphia,PA.
Enterococcal Infections in Transplantation
Compromised Host Conference, Harvard Medical School, Boston, MA.
Xenotransplantation: Risk of Infection in Clinical Xenotransplantation
University of Wisconsin, Madison, WI.
Transplantation Society, Plenary Session, Miami, FLA.
New Pathogens in Hematopoietic Transplantation
Housestaff Conference, MGH, Boston, MA.
American Society of Hematology, Philadelphia, PA.
BK Nephropathy
Transplant Rounds, MGH, Boston, MA.
2003
Visiting Professor, Yale University School of Medicine, New Haven CT.
Infections in Transplantation (Medical Grand Rounds)
Fungal Infections in Transplantation (Surgical Grand Rounds)
Visiting Professor, University of Tennessee School of Medicine, Memphis, TN.
New Challenges in Transplant Infectious Diseases (Surgical Grand Rounds)
Visiting Professor, Drexel University School of Medicine, Philadelphia, PA.
Fungal Infections in the Compromised Host (Medical Grand Rounds-Hahnemann University Hospital)
Clinical Case Conference: The Immunocompromised Host
Viral Infections in Transplantation (Medical Grand Rounds, Medical College of Pennsylvania Campus)
Cytomegalovirus Infections in Transplantation
Northwestern University School of Medicine, Chicago, IL.
University of Pennsylvania School of Medicine, Philadelphia, PA (Surgical Grand Rounds)
Canadian Society for Transplantation, Lake Louise, CA. (Consensus conference on CMV – Health Canada)
International Heart and Lung Transplant Society, Vienna, Austria (Plenary Lecture)
Fungal Infections in Transplantation
Middle Eastern Society of Transplantation (Plenary Lecture), Oman
Viral Infections in Transplantation
Middle Eastern Society of Transplantation (Plenary Lecture), Oman
Boston University School of Medicine (Infectious Disease Conference)
New Pathogens in Hematopoietic Transplantation
MD Anderson Hospital, Medical Grand Rounds, Houston, TX.
Leukemia Conference, MGH, Boston, MA
Polyomavirus and West Nile Virus in Transplantation
American Society of Transplantation, Washington, DC (Plenary Lecture)
Infection in Xenotransplantation
American Society of Transplantation Winter Symposium on “Frontiers of Organ Replacement”, Naples, FLA
AST Fellows Symposium, Dallas, TX.
New Pathogens in Solid Organ Transplantation
University of Southern California, Los Angeles, CA
University of San Diego School of Medicine, San Diego, CA
Oregon State Health Sciences University, Portland OR
Mount Sinai School of Medicine, New York (Medical Grand Rounds)
University of Cincinnati School of Medicine (Surgical Grand Rounds)
Clive Barker Symposium, Phoenix, AZ
MGH Medical Housestaff Conferences:
Infection in the Immunocompromised Host
Fungal Infections
Infection in Transplantation
2004
Visiting Professor, University of Alberta, Edmonton, Canada
New Pathogens in Solid Organ Transplantation
University of Pittsburgh School of Medicine (Transplant Grand Rounds)
American Society of Transplantation Winter Symposium, Scottsdale, AZ.
Visiting Professor, University of Minnesota, Transplant Division
University of Massachusetts, Worcester, MA. Transplant Unit.
Department of Surgery, University of Florida, Gainesville, FL.
14th World Congress of International Association of Surgery and Gastroenterology, Zurich, Switzerland (Plenary Lecture)
Fellows’ Conference, American Society of Transplantation, Dallas, TX.
Fungal Infections in Transplantation
Meet-the-Professor Session, Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, DC
Plenary Session, International Immunocompromised Host Society, Grenada, Spain
Boston University School of Medicine, Infectious Disease Division, Boston, MA.
New Options in Systemic Antifungal Therapy: Combination therapy (Plenary speaker and Program Chair), ICAAC, Washington DC.
Vaccine Development, Bioterrorism and Transplant Recipients
National Institute for Allergy, Infectious Disease, NIH, Bethesda, MD.
Future Directions for Lung Transplantation Workshop, NHLBI, NIH, Bethesda, MD.
A Large Animal Model for Studies of Post-Transplant Lymphoma, Dana Farber Cancer Institute, Bone Marrow Transplant Seminars, Boston, MA.
MGH Medical Housestaff Conferences:
Infection in the Immunocompromised Host
Fungal Infections
Infection in Transplantation
2005
Swiss Society for Transplantation, Interlaken -- Plenary Lectures
Infection and Rejection In Transplantation
Fungal Infections in Transplantation,
Visiting Professor: Swiss National Medical School of Lausanne, SZ. Plenary Speaker at First Research Day
State of the Art: Translational Research and Infections in the Immunocompromised host
Conference Organizer and Plenary Speaker
Donor Derived infection in Transplantation, Centers For Disease Control Workshop on Allograft Associated Infections, Atlanta, GA.
Control of CMV Infection in Cardiac Transplantation, Cardiology Grand Rounds, MGH
Conference Chair and Plenary Speaker:
Transplant Infections: What’s New What’s Hot? The Challenge of PTLD: Answers from EBV and Xenotransplantation. International Society of Heart and Lung Transplantation, Philadelphia, PA.
Transplant Infectious Disease: New Challenges
Boston University Infectious Disease Fellows Conference, Boston, MA
Advanced Heart and Lung Disease: CME Course, Harvard Medical School, Boston
5th Vail Cardiothoracic Transplantation Conference: Vail, Colorado
Overview: Transplant ID, American Transplant Congress, Infectious Disease Course, Seattle, WA.
University of California, Los Angeles, Medical Center (UCLA) Transplant Grand Rounds
Management of the Post-Transplant Patient: A Case-Based Approach, AST Fellows Symposium, Dallas, TX.
Fungal Infections in Transplantation
Plenary Speaker, Liver Transplantation Society of Japan, Fungal Infections in Liver Transplantation, Sapporo, Japan.
5th Vail Cardiothoracic Transplantation Conference: Vail, Colorado
Dumont-UCLA Transplant Center, Los Angeles, CA.
Indirect Effects of Viral Infection in Transplantation, 8th Banff Conference on Transplant Pathology, Edmonton, CA.
Plenary Speaker, Current Concepts of Infection in Xenotransplantation, International Xenotransplantation Society Gothenberg Sweden.
MGH Medical Housestaff Conference
Infection in the Immunocompromised Host
Fungal Infections
Infection in Transplantation
BK Nephropathy, The 9th Annual Aaron Mannett Transplant Lecture, Lankenau Hospital, Philadelphia, PA.
Plenary Speaker: European Society of Transplantation, Geneva, SW.
Viral Infections In Transplantation
Conference Organizer and Plenary Speaker:
Diversity and Disparity in Solid Organ Transplantation: Bench to Bedside, Facts and Solutions A Diversity and Disparity in Transplantation Workshop. Capital Hill, Washington, DC
Program Chair and Plenary Speaker: First Joint Winter Symposium of the American Society of Transplantation and the Canadian Society of Transplantation, Banff, Canada
Infection and Malignancy in Transplantation
2006
Emery University, Atlanta: Visiting Professor – Emerging Infections in Transplantation, Infections in Xenotransplantation
Program Chair and Plenary Speaker: First Joint Winter Symposium of the American Society of Transplantation and the Mexican Society of Transplantation, Cancun, Mexico February 2006
o The Special Challenges of Transplantation in the Developing World
14th Symposium of the International Immunocompromised Host Society, July 2006, Crans-Montana, Switzerland
o Round Table and Meet-the-Expert Session on Infections in Solid Organ Transplant Patients
Infections in Xenotransplantation
University of Minnesota Transplant Grand Rounds, Minneapolis
University of Indiana Surgical Grand Rounds, Indianapolis
International Xenotransplantation Association (IXA), Boston, MA.
Emerging Infections and Donor-Derived Infections in Transplantation
AOPO (Association of Organ Procurement Organizations) Directors’ Meeting, Las Vegas
NATCO Transplant Institute, Scottsdale AZ.
NATCO Annual Meeting, Chicago, IL.
Course Co-Chair: Infection in Transplantation, World Transplant Congress, Boston, July, 2006
Plenary Speaker: World Transplant Congress, Boston, July, 2006
Hot Issues in Infectious Disease: Is CMV an Obsolete Disease?
Overview - The Risk of Infection after Transplantation, Direct and Indirect Effects of Viral Infections
Screening for Infection in Xenotransplantation
Visiting Professor: University of São Paulo Medical School and Latin American Society of Transplantation, Sao Paulo, Argentina.
• Current immunosuppression and effects on the anti-infective immune response
• CMV and other hespesvirus infections in SOT:epidemiology and prophylaxis
• Infection in Xenotransplantation
• Clinical cases in Transplant Infectious Diseases
North American Transplant Coordinators Organization (NATCO), 31st Annual Meeting, Chicago IL.
Curve Balls - New Diseases in Transplantation & Donation
Exotic and Emerging Infectious Diseases
ICAAC (Interscience Conference on Antimicrobial Agents and Chemotherapy): Meet the Expert Session- Approach to Opportunistic Fungal Infections in Solid Organ Transplants, San Francisco, CA.
Rational Screening of Organ Donors for Infectious Diseases, Symposium on Transplant and Transfusion Associated Infections, IDSA (Infectious Disease Society of America), Toronto, Canada.
Harry F. Dowling Day Visiting Professor, University of Illinois School of Medicine, Chicago, IL: Medical/Surgical Grand Rounds, “The Challenge of Infection in Transplantation”; Infectious Disease Rounds: “ Xenotransplantation: Medical Miracle or the Next Great Plague?”
2007
Northwestern University School of Medicine, Chicago, IL, Medical Grand Rounds: “The Challenge of Infection in Transplantation”; & Surgical Grand Rounds: “ Xenotransplantation: Medical Miracle or the Next Great Plague?”; Infectious Disease Rounds: “Fungal Infections in Transplantation”
MGH Medical Housestaff Conferences:
Infection in the Immunocompromised Host
Fungal Infections
Infection in Transplantation
Continuing Medical Education
1982, 1983 Lecturer, Harvard Medical School Continuing Education Series: General Internal Medicine, Emergency Medicine, and Infectious Diseases of Adults
1982, 1983 Lecturer, Massachusetts General Hospital In-Service Training, Department of Nursing
1982-1985 Coordinator, Infectious Disease Pathology Conference, Department of Medicine, Massachusetts General Hospital
1986-1987 Molecular Biology for Physicians, Infectious Disease Unit, M.G.H., Originator and Lecturer
1986-2000 Postgraduate Course “Infectious Diseases of Adults”: Lecturer on: DNA probes in Clinical Diagnosis; Opportunistic Infections in AIDS; Pneumocystis carinii
1990-2001 Director, Extramural Teaching, Infectious Disease Unit, M.G.H.
1990- Course Director, Infectious Diseases of Adults (Harvard/M.G.H.)
1991-2001 Postgraduate Course: "Internal Medicine"; Harvard Medical School, “Opportunistic Infections”, “Clinical Infectious Disease”
1996-2004 Infectious Disease Rounds, (weekly) Department of Anesthesia, M.G.H.
1996-2000 Medical Attending, Teaching Rounds, Salem-North Shore Medical Center (monthly), Salem, MA
1998- Infections in Transplantation, Postgraduate Course in Clinical Nephrology, Harvard Medical School, Boston, MA -- annual lecture
1999-2003 Pulmonary and Critical Care Medicine Course (Harvard/MGH): Community Acquired Pneumonia, -- annual lecture
2001- Brigham and Women’s Hospital/Harvard Board Review in Nephrology, Infection in Transplantation, annual lecture
2001-2006 American Society of Nephrology Postgraduate Course in Transplantation, Infections in Transplantation, annual lecture
2003- Postgraduate Course “Infectious Diseases of Adults”: Infections in the Immunocompromised Host, Cases Studies in Infectious Diseases, annual lecture
2001-2004 Postgraduate Course “Internal Medicine”: Infections in the Immunocompromised Host
2001-2005 American Society of Transplantation Transplant Fellows Symposium, Infections in Transplantation, Case Sessions in Transplantation
2006- Harvard Medical School-Massachusetts General Hospital, Postgraduate Course: Internal Medicine (Pneumonia)
2006- CAQ Course in Transplant Hepatology (Transplant Infectious Diseases)
2006- HMS Heart and Lung Transplantation (Transplant Infectious Diseases)
2006- HMS Critical Care Medicine Course (Fungal Infections in the ICU)
Advisory and Supervisory Responsibilities
1994-2001 Senior Fellow for Advanced Biomedical Sciences, Oliver Wendell Holmes Society, Harvard Medical School, Direction of Theses for Research for 20 students/year, coordinate evaluations and credit reporting, particiapte in course development for ABS Requirements of HMS, meet with each student and participate in science mentoring for two students per year.
1989- Infectious Disease Attending Physician (M.G.H.) with two fellows, 1-2 residents and 1-2 HMS students/month for two months per year
1994- Transplantation Infectious Disease Attending Physician with one infectious disease fellow per month for 4 months per year
1997-2001 Director of Research Laboratories of the Infectious Disease Unit at MGH-East (Charlestown Campus)
1994- Postdoctoral Fellows in Research Laboratory (1-2 per year) weekly meetings with individuals and group (7 hours per week)
2001- Director, Transplant Infectious Disease and Compromised Host Service, MGH. (7 hours per week, 6 faculty, 1 first year Infectious Disease Fellow and 1 second year clinical Fellow), international visiting fellows and faculty
2006- Associate Director, MGH Transplant Center. Primary responsibility for Educational programs (patient and physician) and Database development (clinical and research) for all MGH Transplantation Programs. Overall co-responsibility for budgets and new program development for MGH Transplant Center.
B. Professional and Educational Leadership Roles Related to Teaching
• 1983-1986: Harvard Medical School - New Pathway Planning Group: Course Director and Instructor: Designed and directed first Microbiology and Infectious Disease Lecture/Laboratory Courses of the “New Pathway”. For first group of 68 students per year for two years selected all lecturers, wrote and presented case series (including first AIDS cases), directed and taught both laboratory sections until curriculum became generalized for entire HMS student body.
• 1983-1987 HMS - Subcommittee on Human Biology (Defense Mechanisms)
• 1983-1991: HMS Instructor, Pathophysiology of Infectious Disease (laboratory and conference leader, Harvard Medical School 708.0
• 1989-2003: HMS - Originator/Advisor: Proposed and participated in the first Advanced Basic Science Requirement from the Holmes Society of HMS and served as sole ABS advisor for Holmes Society.
• 1989-1992: Massachusetts General Hospital (MGH) Course Originator: Designed and sole faculty for Molecular Biology for Physicians course for Infectious Disease Staff (8 lectures/year for 4 years)
• 1992-95: MGH - Course Director: Directed and sole faculty for Parasitology Course for Infectious Disease Unit prepared all course materials, organized fellow teaching, arranged demonstrations, selected expert lecturers
• 1994-: MGH – Mentorship for Postdoctoral Fellows in Research Laboratory (1-2 per year) weekly meetings with individuals and group (7 hours per week), publication review
• 1995-: Harvard Medical School CME - Course Co-Director for Infectious Diseases of Adults Course: Redesigned and expanded from 80 to 220 students per year with among highest ratings among HMS CME Courses (1995, 1996, 1997, 1998, 1999, 2000-2006); responsible for course content and syllabus.
• 2001-2004: HMS CME - Section Director and Lecturer for Infectious Diseases for MGH Internal Medicine CME Course
• 1996: American College of Physicians- Section Director: Developed Interactive Infectious Disease Curriculum Course in Internal Medicine (1996, Dr. A. Goroll, director)
• 1997: Guidelines Development for the FDA and WHO/OECD (Xenotransplanation)
• 1998: Guidelines Committee: Canadian Society of Transplantation (CMV)
• 1998: Transplantation Society - Organizing Committee for the Transplantation Infectious Disease World Congress (Orlando)
• 1998-: AST - Session Coordinator and Chair: First Infectious Disease Plenary Session at the American Transplant Congress (multiple sessions annually since 1998)
• 2000: Transplantation Society - Organizing Committee for the Transplantation Infectious Disease World Congress (Rome)
• 2001-: Director, Transplant Infectious Disease and Compromised Host Service, MGH. (7 hours per week, 6 faculty, 1 first year Infectious Disease Fellow and 1 second year clinical Fellow), international visiting fellows and faculty, weekly conference, housestaff education
• 2003: American Society of Transplantation (AST) - Started Infectious Disease Community of Practice (Initiated development of guidelines for infectious disease in transplantation)
• 2000-2005: AST - Program Co-Chair and lecturer for AST Fellows Symposium (Co-chair AST Education Committee)
• 2004: AST – Appointed first Infectious Disease specialist to Program Committee of American Transplant Congress (as President of AST)
• 2004: AST - Program Chair, Postgraduate course on Infectious Diseases in Transplantation, American Transplant Congress
• 2005: Program Co-Chair: First Joint AST-Canadian Transplant Fellows Symposium with Canadian Society of Transplantation (Banff)
• 2005: Program Co-Chair and Plenary Speaker, First Joint AST-European Society of Transplantation Session (Geneva)
• 2006: Program Co-Chair: First Joint AST-Mexican Society of Transplantation (Cancun)
• 2004-2006: Chaired Project Committee, first web-based educational program for transplant recipients (HealthyTransplant.com), Chaired Infection and Malignancy Subcommittee Release July, 2006.
• 2004: Transplantation Society - Program Committee for Congress (Vienna)
• 2005: Transplant Virology (www.transplant-virology.com). Designed and wrote all content for web-based ACCME-accredited program to provide teaching materials and CME credit via the Internet. Released 2005
• 2005-2007: Project chair and speaker: Invasive Fungal Infections: Treatment Advances and Challenges, ACCME Accredited CME Audioconference Series
• 2005: Appointed first Diversity and Minority Affairs Committee for AST (Program Co-Chair, first national consensus conference on Diversity and Minority Access in Transplantation, 9/05)
• 2005: AST - Program Chair, Postgraduate Course on Infectious Diseases in Transplantation, American Transplant Congress
• 2006-: Chair, Transplant Transmission Advisory Committee and Chair, Transplant Transmission Sentinel Network, Centers for Disease Control and Prevention-United Network of Organ Sharing (UNOS/OPTN) (2006): Directing the development of web-based reporting network for epidemiology of transmission of malignancy and infection with tissue and organ allografts
• 2006: Program Co-Chair: 2007 Workshop on Allograft-associated Disease Transmission (CDC)
• 2005-2006: Program Co-Chair, Infectious Diseases Section, World Transplant Congress, (Boston)
• 2006: World Transplant Congress - Postgraduate Course: Essentials of Transplant Infectious Disease (Audience Response Program) Co-Chair and Speaker
• 2006: American Society of Microbiology ICAAC (Interscience Conference on Antimicrobial Agents and Chemotherapy): Meet the Expert Session- Approach to Opportunistic Fungal Infections in Solid Organ Transplants (San Francisco)
• 2006: Infectious Disease Society of America - Co-Chair/Speaker: Symposium on Transplant and Transfusion Associated Infections Toronto, Canada.
• 2006-: Program Committee, Infectious Diseases, International Transplantation Society (TTS) Congress 2008 (Sydney, Australia)
• 2006-: Associate Director, MGH Transplant Center: Chair, Database and Educational Subcommittees
Special accomplishments in Education:
A major career goal has been to establish Transplantation Infectious Disease as an integral component of the clinical care of organ transplantation recipients. I have been able to accelerate this process via leadership roles in education at Massachusetts General Hospital, Harvard Medical School, at the American Society of Transplantation (AST Education Committee, Board of Directors, and as President), and internationally. Trainees from the MGH Transplant Infectious Disease and Compromised Host Program are leading Transplant Infectious Disease Programs at major centers nationally. I have been a Co-Director for the Harvard Medical School Infectious Diseases of Adults CME course since 1990 and been a speaker in many HMS CME courses. On multiple occasions, I have organized and co-chaired both the AST Fellows Symposium and clinical and basic science plenary sessions in Transplantation and Infectious Disease the major Infectious Disease (ICAAC, IDSA) and transplantation societies (American Transplant Congress, International Heart and Lung Transplant Society, European Society of Transplantation, The Transplantation Society, International Immunocompromised Host Society, Middle Eastern Society of Transplantation, Latin American Society of Transplantation, Brazilian Transplant Society). As President of AST, I organized the first joint meetings with the Canadian, European and Mexican Transplant Societies. I have given numerous invited lectures and served as a visiting professor at major transplant centers in the U.S. and internationally. The reach of CME programs has been expanded using web-based educational programs and audioconferences. The Career Achievement Award of the American Society of Transplantation recognized my role in clinical care and education. One of my roles as Associate Director of the new MGH Transplantation Center will be to continue to develop novel educational programs for community and academic clinicians and for transplant donors and recipients.
3. Teaching Awards:
2002: Career Achievement Award of the American Society of Transplantation
4. Major Curriculum Offerings:
Educational Programs:
1994-2001 Senior Fellow for Advanced Biomedical Sciences, Oliver Wendell Holmes Society, Harvard Medical School, Direction of Theses for Research for 20 students/year, coordinate evaluations and credit reporting, particiapte in course development for ABS Requirements of HMS, meet with each student and participate in science mentoring for two students per year.
1989-2000 Infectious Disease Attending Physician (M.G.H.) with two fellows, 1-2 residents and 1-2 HMS students/month for two months per year
1994-2000 Clinical Director, Transplantation Infectious Disease Program - one infectious disease fellow per month for 4 months per year
1994- Postdoctoral Fellows in Research Laboratory (1-2 per year) weekly meetings with individuals and group (7 hours per week)
1995- Harvard Medical School CME - Course Co-Director for Infectious Diseases of Adults Course: Redesigned and expanded from 80 to 220 students per year with among highest ratings among HMS CME Courses (1995, 1996, 1997, 1998, 1999, 2000-2006); responsible for course content and syllabus.
2001- Director, Transplant Infectious Disease and Compromised Host Service, MGH. (7 hours per week, 6 faculty, 1 first year Infectious Disease Fellow and 1 second year clinical Fellow), international visiting fellows and faculty
2006- Transplant Infectious Disease rotation offered to Medical Housestaff, MGH
2007- Associate Director, MGH Transplantation Center (Chair Education Committee)
Other Educational Programs:
• 1998: Fishman JA, Brennen, D. Post-Transplant Infections: ASTP Teaching Slide Set. Amer Soc Transplant Physicians, November 1998.
• 1998: Turgeon N, Fishman JA. The Pretransplant Evaluation, in Up to Date, CD ROM textbook.
• 1999: Fishman JA. Infections in Transplantation, in Up to Date, CD ROM.
• 1999: Fishman JA. Pulmonary Infection in the Immunocompromised Host, in Up to Date, CD ROM.
• 2001: Alexander B, Fishman JA. Prophylaxis in solid organ transplantation, in Up to Date, CD ROM.
• 2002: Fishman JA. New Options in Antimicrobial Therapy in Patients with Cancer or Bone Marrow Transplantation, CD ROM, ASH, December.
• 2002: Fishman JA. New Perspectives on Cytomegalovirus in Solid Organ Transplantation. CD-ROM, CME Program, Indiana University School of Medicine.
• 2002: Rubin RH, Fishman JA, Avery R. New Perspectives on Cytomegalovirus in Transplantation, A CME Program, (Slides and text), University of Indiana.
• 2003: Fishman JA. Invasive Fungal Infections in Solid Organ Transplantation. CD-DVD.
• 2003: Fishman JA. Indirect Effects of Cytomegalovirus Infection in Transplantation. CD-DVD, (web-based). VPG Integrated Media, Boston.
• 2003: Fishman, JA. Editor, International Immunocompromised Host Society Mycology Initiative, “Fungal Infections in Solid Organ Transplant Recipients” CD ROM and Slide Set
• 2003: Managing Infections in Patients with Hematologic Maligancies (CD Rom and Slide Set) (Editor, John Wingard)
• 2004-5: Alexander B, Fishman JA. Prophylaxis in solid organ transplantation (1 and 2), in Up to Date, on line and CD ROM.
• 2004-2006: Kauffman, CA, Fishman JA, Kubak B, Patterson TF, Perfect JR. Fungal Infections In Solid Organ Transplant Recipients. International Immunocompromised Host Society Mycology Initiative 2004-2005. CME Monograph:
• 2004-2006: Chaired Project Committee, first web-based educational program for transplant recipients (HealthyTransplant.com), Co-Chair Infection and Malignancy Subcommittee Released July, 2006.
• 2005: Transplant Virology (www.transplant-virology.com). Designed and wrote all content for web-based ACCME-accredited program to provide teaching materials and CME credit via the internet. Released 2005
• 2005-2007: Project chair and speaker: Invasive Fungal Infections: Treatment Advances and Challenges, ACCME Accredited CME Audioconference Series
Teaching, clinical care, research, and/or community contributions
My professional career has been devoted to the integration of clinical care of solid organ and hematopoietic transplant recipients, studies of the molecular biology of pathogens in immunocompromised hosts, and teaching and leadership roles in Infectious Diseases in the United States and internationally. My major contributions have included:
Achieving the recognition of Transplant Infectious Disease as an essential subspecialty of clinical transplantation. This has been recognized by my election as the first Infectious Disease clinician-scientist as President of the American Society of Transplantation (AST). As President of the AST, I have been able to impact a series of important areas in the field of organ transplantation:
Expanded clinical and basic science fellowship awards in transplantation
International links with Canadian, Mexican and European Transplant Societies
Represented US Transplant Physicians at the First World Transplant Day (WHO)
Program Chair for Infectious Disease for the first joint meeting with the international Transplantation Society (Boston, 2006).
Appointed the first national committee on Diversity and Minority Affairs in Transplantation and convened the first national conference on Minority and Underserved Populations in Transplantation (September 2005).
Redesigned the criteria used in US organ donor screening by the Association of Organ Procurement Organizations and by the United Network of Organ Sharing (UNOS).
First Infectious Disease specialist on the Data Safety Monitoring Board for Transplant Programs at the NIH and in the Immune Tolerance Network; Only infectious disease specialist on the Operations Committee of UNOS and chair the CDC Advisory Committee developing a Surveillance system for Infections in Allotransplantation.
Nominated for the Secretary’s (U.S. Department of Health and Human Services) Advisory Committee on Transplantation
Development of guidelines for xenotransplantation by the World Health Organization, Health Canada, the US Food and Drug Administration and at Harvard Medical School
Training of young clinicians and investigators in Transplant Infectious Disease via development of the Transplant Infectious Disease and Compromised Host Program at the Massachusetts General Hospital. This program integrates all aspects of clinical care, basic, clinical, and translational research, and education devoted to patients with immune deficits at Massachusetts General Hospital.
Clinical investigation of new therapies for infections due to Pneumocystis carinii, viral and fungal pathogens in immunocompromised hosts – first cloning of surface antigens of Pneumocystis.
Molecular biology of potential pathogens associated with pig-to-human xenotransplantation including the first full-length cloning and sequencing of porcine endogenous retrovirus.
Major teaching roles at Harvard Medical School and internationally.
Co-directorship of the HMS Infectious Diseases of Adults Postgraduate since 1990- one of the highest rated of the HMS CME courses every year
Chaired the Transplant Infectious Disease Conference of AST; Organizing Committees for Transplantation Infectious Disease World Congresses (Orlando, 4/98; Rome 2000), Transplantation Society Congresses (Rome 2000, Vienna 2004, Boston 2006).
Physician Trainees of the M.G. H. Transplant Infectious Disease Program
Barbara Alexander Duke University Chief, Transplant Infectious Disease Chief, Transplant Infectious Disease, Asst Professor
Ban Hock Tan Singapore Head, Infectious Disease for Hematology-Oncology Chief, Infectious Disease in Oncology
Mun Sam Lam Singapore Chief, Transplant Infectious Disease Consultant, Transplant Infectious Disease
Atul Humar University of Toronto Chief, Transplant Infectious Disease
Dino Sgarabotto University of Padua Consultant, Transplant and Oncology ID
Ana Maria Contreras Guadalajara, Mexico Infectious Disease Research: Hepatitis B
Albert Shaw Yale University, Basic Immunology Research Assistant Professor, Infectious Disease
Nicolas Mueller University of Zurich Assistant Professor, Transplant Infectious Disease and HIV
Karen Doucette University of Alberta Co-Director Transplant Infectious Disease and HIV-HCV Co-infection Program, Assistant Professor
Costi Sifri University of Virginia Assistant Professor, Infectious Disease
Michael Ison Northwestern University Director, Transplant Infectious Disease, Asst. Professor
Camille Kotton Mass. General Hospital Transplant Infectious Disease Clinician
Stanley Martin Ohio State University Transplant Infectious Disease Clinician, Asst. Professor
Bibliography
Original Reports:
1. Fishman JA, Pietra GG. Gill permeability to lipid-insoluble macromolecules in the dogfish, Squalus acanthias. Bull Mt Desert Island Biol Lab. 1973; 13:36-41.
2. Fishman JA, Ryan GB, Karnovsky MJ. Endothelial regeneration in the rat carotid artery and the significances of endothelial denudation in the pathogenesis of myo-intimal thickening. Laboratory Investigation. 1975; 32:339-351.
3. Charness M, Fishman JA, Robertson D. Exacerbation of angina pectoris by prazocin. Southern Med J. 1979; 72:1213-1218.
4. Fishman JA, Pietra GG, Daniele RP. Lung defenses in the African lungfish (Protopterus): Cellular responses to irritant stimuli. J Reticuloendothelial Soc. 1979; 25:179-195.
5. Fishman JA, Martell KM, Rubin RH. Infection and T-lymphocyte subpopulations; changes associated with bacteremia and the acquired immunodeficiency syndrome. Diagnostic Immunol. 1983; 1:261-265.
6. Ruoff KL, Fishman JA, Calderwood SJ, Kunz LJ. Identification and pathogenicity of viridans streptococci from clinical specimens. Am J Clin Path. 1983;80:854-858.
7. Fishman JA, Perrone T. Colonic obstruction and perforation due to Trichuris Trichiura. Am J Med. 1984; 77:154-156.
8. Fishman JA, Karnovsky MJ. An in vitro model of aminonucleoside nephrotoxicity. Am J Path. 1985; 118:398-407.
9. Karnovsky MJ, Fishman JA, Ryan GB, Clowes AW, Guyton JR, Rosenberg RD. "Experimental Model for Atherosclerosis". In: Atheroma and Thrombosis. VV Kakkar, editor, Pitman Publishing Limited, London 1985, pp. 50-58.
10. Bartlett, M.B., Fishman, J.A., Queener, S.F., Durkin, M.M., Jay, M.A., Smith,J.W. A new rat model of Pneumocystis carinii. J. Clin. Microbiol. 1988; 6:1100-1102.
11. Bogucki, MS, Fishman, JA, Radding, JA, Armstrong, MK, Richards, FF Immunochemical characterization of Pneumocystis carinii protein antigens using monoclonal antibodies. Soc. Protozoologists. 1988;53-57.
12. Bartlett MS, Fishman JA, Durkin MM, Queener SF, Smith JW. Pneumocystis carinii: Improved models to study efficacy of drugs for treatment or prophylaxis of Pneumocystis pneumonia in the rat Exp. Parasitol. 1990; 70:100-106.
13. Fishman JA, Strauss HW, Fischman AJ, Nedelman M, Callahan R, Khaw B-A, Rubin RH. Imaging of Pneumocystis carinii pneumonia with Indium-labeled non-specific polyclonal IgG: An experimental study in rats. Nuc. Med. Comm. 1991; 12: 175-187.
14. Fishman JA, Samia JS, Fugelstad J, Rose RR. Effects of Extracellular Matrix Proteins on the attachment of Pneumocystis carinii to Mesenchymal cells in vitro. J. Protozool. 1992; 38:34-35S.
15. Mirovsky P, Fishman JA. An improved method for the long term maintenance of Pneumocystis carinii in vitro. J. Infect. Dis. 1993, 167:1470-1473.
16. Fishman JA, Queener SF, Roth RS, Bartlett MS. The activity of Topoisomerase inhibitors against Pneumocystis carinii in vitro and in the inoculated mouse model. Antimicrob. Agents Chemother., 1993, 37:1543-1546.
17. Kandil O, Fishman JA, Koziel H, Pinkston P, Rose RM, Remold HG. Human immunodeficiency virus type 1 infection of human macrophages modulates the cytokine response to Pneumocystis carinii Infect. Immun. 1994, 62:644-650.
18. Fishman JA, Roth RS, Zanzot E, Enos EJ, Ferraro MJ. Use of Induced Sputum specimens for the Microbiologic Diagnosis of Infection due to Organisms other than Pneumocystis carinii. J. Clin. Microbiol., 1994, 32:131-134.
19. Fishman JA. Miniature swine as organ donors for man: strategies for prevention of xenotransplant-associated infections. Xenotransplantation, 1994, 47-57.
20. Furlong SA, Samia JA, Rose RM, Fishman JA. Phytosterols are present in Pneumocystis carinii Antimicrobial Agents Chemother,1994, 38:2534-2540.
21. Phelps D, Umstead TM, Rose RM, Fishman JA. Surfactant protein-A levels increase during Pneumocystis carinii pneumonia in the rat. Eur. Resp. J. 1996 9:565-570.
22. Sablinski T, Gianello P, Bailin M, Bergen KS, Emery DW, Fishman JA, Foley A, Hatch T, Hawley B, Kozlowski T, Lorf T, Meehan S, Monroy R, Powelson JA, Colvin R, Cosimi AB, Sachs DH. Pig to Monkey Bone Marrow and Kidney Xenotransplantation. Surgery 1997, 121:381-91.
23. Zhao Y, Fishman JA, Sergio JJ, Oliveros JL, Pearson DA, Szot GL, Arn JS, Sachs DH, Sykes M. Immune Restoration by Fetal Pig Thymus Grafts in T cell-depleted, Thymectomized mice. J Immunol. 1997,158:1641-1649.
24. Emery DM, Sablinski T, Shimada H, Germana S, Gianello P, Foley A, Schulman S, Arn S, Fishman J, Lorf T, Nickeleit V, Colvin RB, Sachs DH, LeGuern C. Expression of an allogeneic MHC DRB Transgene, through retroviral transduction of bone marrow, induces specific reduction of alloreactivity. Transplantation, 1997,64:1414-1423.
25. Kozlowski T, Fuchimoto Y, Monroy R, Bailin M, Martinez-Ruiz R, Foley A, Xu Y, Awwad M, Fishman J, Andrews D, Ritzenthaler J, Sablinski T, Ierino FL, Sachs DH. Apheresis and column absorption for specific removal of Gal-alpha-1,3 Gal natural antibodies in a pig-to-baboon model. Transplant Proc., 1997, 29:961.
26. Akiyoshi DE, Denaro M, Zhu H, Greenstein JL, Banerjee P, Fishman J. Identification of a Full-length cDNA for an Endogenous Retrovirus of Miniature Swine. J. Virology, 1998, 72:4503-4507.
27. Koziel H, Phelps DS, Fishman J, Armstrong MYK, Richards FF, Rose RM. Surfactant Protein-A reduces binding and phagocytosis of Pneumocystis carinii by human alveolar macrophages in vitro. Amer. J. Resp. Cell Molec. Biol., 1998, 18: 834-843.26.
27. Lambrigts D, van Calster P, Xu Y, Awwad M, Neethling FA, Kozlowski T, Foley A, Watts A, Chae SJ, Fishman J, Thall AD, White-Scharf ME, Sachs DH, Cooper DKC. Pharmacologic immunosuppressive therapy and extracorporeal immunoadsorption in the suppression of anti-gal antibody in the baboon. Xenotransplantation 1998, 5, 274-283.
28. Turgeon N, Fishman JA, Basgoz N, Tolkoff-Rubin NE, Cosimi AB, Rubin RH. Effect of oral acyclovir or gancyclovir after preemptive intravenous ganciclovi
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